How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm

S Jana, M Hu, M Shen, Z Kassiri - Experimental & molecular medicine, 2019 - nature.com
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …

Cyclophilin A: a key player for human disease

P Nigro, G Pompilio, MC Capogrossi - Cell death & disease, 2013 - nature.com
Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin
family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates …

Pathophysiology and epidemiology of abdominal aortic aneurysms

IM Nordon, RJ Hinchliffe, IM Loftus… - Nature reviews …, 2011 - nature.com
Abdominal aortic aneurysms (AAAs) are found in up to 8% of men aged> 65 years, yet
usually remain asymptomatic until they rupture. Rupture of an AAA and its associated …

AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Wnt signaling pathway inhibitor sclerostin inhibits angiotensin II–induced aortic aneurysm and atherosclerosis

SM Krishna, SW Seto, RJ Jose, J Li… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—Sclerostin (SOST) has been identified as an important regulator of bone
formation; however, it has not been previously implicated in arterial disease. The aim of this …

[图书][B] Diagnostic ultrasound

CM Rumack, D Levine - 2017 - books.google.com
Now fully updated with more than 2,000 new images and new content throughout,
Diagnostic Ultrasound, 5th Edition, by Drs. Carol M. Rumack and Deborah Levine, remains …

The UK EndoVascular Aneurysm Repair (EVAR) randomised controlled trials: long-term follow-up and cost-effectiveness analysis.

R Patel, JT Powell, MJ Sweeting, DM Epstein… - 2018 - repository.cam.ac.uk
BACKGROUND: Short-term survival benefits of endovascular aneurysm repair (EVAR)
compared with open repair (OR) of intact abdominal aortic aneurysms have been shown in …

[HTML][HTML] Metformin prescription status and abdominal aortic aneurysm disease progression in the US veteran population

NK Itoga, KA Rothenberg, P Suarez, TV Ho… - Journal of vascular …, 2019 - Elsevier
Background Identification of a safe and effective medical therapy for abdominal aortic
aneurysm (AAA) disease remains a significant unmet medical need. Recent small cohort …