The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …

The immune system plays a pivotal role in the initiation, development and resolution of
inflammation following insult or damage to organs. The heart is a vital organ which supplies …

Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Aims Acute myocardial infarction (MI) is the leading cause of mortality worldwide. Anti-
inflammatory strategies to reduce neutrophil-driven acute post-MI injury have been shown to …

Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial
signaling were shown to be specifically altered in heart failure with preserved ejection …

Cardiac cell therapy holds a real promise for improving heart function and especially of the
chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better …

Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction
(HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF …

Laboratory studies of the heart use cell and tissue cultures to dissect heart function yet rely
on animal models to measure pressure and volume dynamics. Here, we report tissue …

Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac
fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …