Biochemical mechanisms of vertebrate hedgehog signaling
Signaling pathways that mediate cell-cell communication are essential for collective cell
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …
Gli proteins in development and disease
Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …
Structural basis of Smoothened regulation by its extracellular domains
Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the
membrane by Frizzled-class G-protein-coupled receptors (GPCRs) composed of both a …
membrane by Frizzled-class G-protein-coupled receptors (GPCRs) composed of both a …
Hedgehog: functions and mechanisms
M Varjosalo, J Taipale - Genes & development, 2008 - genesdev.cshlp.org
The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …
[HTML][HTML] Hedgehog signaling in development and cancer
The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during
embryonic development and adult tissue homeostasis. Here we review the current …
embryonic development and adult tissue homeostasis. Here we review the current …
[HTML][HTML] Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We
find that cholesterol is not just necessary but also sufficient to activate signaling by the …
find that cholesterol is not just necessary but also sufficient to activate signaling by the …
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
E Dessaud, AP McMahon, J Briscoe - 2008 - journals.biologists.com
Neuronal subtype specification in the vertebrate neural tube is one of the best-studied
examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a …
examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a …
[HTML][HTML] Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
Recognition of the multiple roles of Hedgehog signaling in cancer has prompted intensive
efforts to develop targeted pathway inhibitors. Leading inhibitors in clinical development act …
efforts to develop targeted pathway inhibitors. Leading inhibitors in clinical development act …
Hedgehog beyond medulloblastoma and basal cell carcinoma
S Teglund, R Toftgård - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2010 - Elsevier
The Hedgehog (Hh) signaling pathway is of central importance during embryo development
in metazoans and governs a diverse array of processes including cell proliferation …
in metazoans and governs a diverse array of processes including cell proliferation …
[HTML][HTML] Rac1 activation controls nuclear localization of β-catenin during canonical Wnt signaling
Canonical Wnt signaling critically regulates cell fate and proliferation in development and
disease. Nuclear localization of β-catenin is indispensable for canonical Wnt signaling; …
disease. Nuclear localization of β-catenin is indispensable for canonical Wnt signaling; …