Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) have recently
entered the therapeutic armamentarium of clinical oncologists, and show promising activity …

Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery
and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at …

Abstract Cyclin-dependent kinase (CDK) 4/6 inhibition in combination with endocrine
therapy is the standard-of-care treatment for patients with advanced-stage hormone receptor …

Inactivation of the RB protein is one of the most fundamental events in cancer. Coming to a
molecular understanding of its function in normal cells and how it impedes cancer …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

The function and activity of a protein are often modulated by other proteins with which it
interacts. This review is intended as a practical guide to the analysis of such protein-protein …

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as
both activators and repressers of gene expression. A nuclear receptor co-repressor (N-CoR) …

Newly described classes of G, cyclins and their cyclindependent kinases (cdks) are proving
to be integrators of growth factor-mediated signals that drive the cell cycle. Growth factors act …