Leptin is hypothesized to function as a negative feedback signal in the regulation of energy
balance. It is produced primarily by adipose tissue and circulating concentrations correlate …

The discovery of the archetypal adipocytokine leptin and how it regulates energy
homeostasis have represented breakthroughs in our understanding of the endocrine …

Being overweight or obese, as measured with body-mass index or central adiposity (waist
circumference), and the trajectory of body-mass index over the life course have been …

The discovery of leptin has enhanced understanding of the interrelationship between
adipose energy stores and neuronal circuits in the brain involved in energy balance and …

Obesity, particularly the abdominal phenotype, is associated with several reproductive
disturbances. Whereas mechanisms by which obesity affect fertility are complex and still not …

Obesity is increasing at unprecedented levels globally, and the overall impact of obesity on
the various organ systems of the body is only beginning to be fully appreciated. Because of …

Despite the high prevalence of obesity, eating disorders, and weight-related health
problems in modernized cultures, the neural systems regulating human feeding remain …

The discovery of leptin was a major breakthrough in our understanding of the role of adipose
tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent …

Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for
multiple conditions and contributes to multi-morbidities, resulting in increased health costs …

As the world faces an obesity “epidemic,” the mechanisms by which overweight is translated
into insulin resistance, hypertension, and diabetes need to be better understood. Although …