The endocannabinoid system and cannabidiol's promise for the treatment of substance use disorder

Y Chye, E Christensen, N Solowij, M Yücel - Frontiers in psychiatry, 2019 - frontiersin.org
Substance use disorder is characterized by repeated use of a substance, leading to
clinically significant distress, making it a serious public health concern. The …

Role of cannabidiol in the therapeutic intervention for substance use disorders

F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2021 - frontiersin.org
Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …

Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-HT1A and TRPV1 receptor mechanisms

E Galaj, GH Bi, HJ Yang, ZX Xi - Neuropharmacology, 2020 - Elsevier
Cocaine abuse continues to be a serious health problem worldwide. Despite intense
research there is currently no FDA-approved medication to treat cocaine use disorder. The …

Cannabidiol and substance use disorder: Dream or reality

S Karimi-Haghighi, Y Razavi, D Iezzi, AF Scheyer… - …, 2022 - Elsevier
Background Cannabidiol (CBD) is one of the major constituents of Cannabis sativa L. that
lacks psychotomimetic and rewarding properties and inhibits the rewarding and reinforcing …

Sex differences in the neuropsychiatric effects and pharmacokinetics of cannabidiol: A scoping review

J Matheson, Z Bourgault, B Le Foll - Biomolecules, 2022 - mdpi.com
Cannabidiol (CBD) is a non-intoxicating cannabinoid compound with diverse molecular
targets and potential therapeutic effects, including effects relevant to the treatment of …

Cannabidiol in the context of substance use disorder treatment: A systematic review

V Paulus, J Billieux, A Benyamina, L Karila - Addictive behaviors, 2022 - Elsevier
Introduction Cannabidiol (CBD) is a phytocannabinoid found in the Cannabis plant. CBD
has received significant medical attention in relation to its anticonvulsant, anxiolytic, and …

Cannabidiol treatment might promote resilience to cocaine and methamphetamine use disorders: a review of possible mechanisms

C Calpe-López, MP García-Pardo, MA Aguilar - Molecules, 2019 - mdpi.com
Currently, there are no approved pharmacotherapies for addiction to cocaine and other
psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a …

Possible receptor mechanisms underlying cannabidiol effects on addictive-like behaviors in experimental animals

E Galaj, ZX Xi - International Journal of Molecular Sciences, 2020 - mdpi.com
Substance use disorder (SUD) is a serious public health problem worldwide for which
available treatments show limited effectiveness. Since the legalization of cannabis and the …

Potential of cannabinoid receptor ligands as treatment for substance use disorders

E Galaj, ZX Xi - CNS drugs, 2019 - Springer
Substance use disorder (SUD) is a major public health crisis worldwide, and effective
treatment options are limited. During the past 2 decades, researchers have investigated the …

Glial cell AMPA receptors in nervous system health, injury and disease

M Ceprian, D Fulton - International journal of molecular sciences, 2019 - mdpi.com
Glia form a central component of the nervous system whose varied activities sustain an
environment that is optimised for healthy development and neuronal function. Alpha-amino …