Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are
evident in the brain and spinal cord of patients that present across a spectrum of …

Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis with
associated frontotemporal dementia (ALS/FTD) are major neurodegenerative diseases for …

Mitochondria and the endoplasmic reticulum (ER) form tight structural associations and
these facilitate a number of cellular functions. However, the mechanisms by which regions of …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have distinct clinical
features but a common pathology—cytoplasmic inclusions rich in transactive response …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease affecting upper and
lower motor neurons in the central nervous system. Patients with ALS develop extensive …

Amyotrophic lateral sclerosis (ALS) is a devastating, uniformly lethal degenerative disorder
of motor neurons that overlaps clinically with frontotemporal dementia (FTD). Investigations …

Significance: There is increasing evidence that the generation of reactive oxygen species
(ROS) in the central nervous system (CNS) involves the NOX family of nicotinamide adenine …

Defective FUS metabolism is strongly associated with amyotrophic lateral sclerosis and
frontotemporal dementia (ALS/FTD), but the mechanisms linking FUS to disease are not …

There exists a phenomenon in aging research whereby early life stress can have positive
impacts on longevity. The mechanisms underlying these observations suggest a robust, long …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving
both upper motor neurons (UMN) and lower motor neurons (LMN). Enormous research has …