Cell surface remodeling by plasmin: a new function for an old enzyme

EI Deryugina, JP Quigley - BioMed Research International, 2012 - Wiley Online Library
Plasmin, one of the most potent and reactive serine proteases, is involved in various
physiological processes, including embryo development, thrombolysis, wound healing and …

The role of the plasminogen/plasmin system in inflammation of the oral cavity

T Yatsenko, M Skrypnyk, O Troyanovska, M Tobita… - Cells, 2023 - mdpi.com
The oral cavity is a unique environment that consists of teeth surrounded by periodontal
tissues, oral mucosae with minor salivary glands, and terminal parts of major salivary glands …

Role of mesenchymal stem cell-derived fibrinolytic factor in tissue regeneration and cancer progression

B Heissig, D Dhahri, S Eiamboonsert, Y Salama… - Cellular and molecular …, 2015 - Springer
Tissue regeneration during wound healing or cancer growth and progression depends on
the establishment of a cellular microenvironment. Mesenchymal stem cells (MSC) are part of …

The annexin A2 system and angiogenesis

W Liu, KA Hajjar - Biological chemistry, 2016 - degruyter.com
The formation of new blood vessels from pre-existing vasculature, the process known as
angiogenesis, is highly regulated by pro-and anti-angiogenic signaling molecules including …

Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9–mediated cytokine release from myeloid cells

S Munakata, Y Tashiro, C Nishida, A Sato… - Gastroenterology, 2015 - Elsevier
Background & Aims Activated proteases such as plasmin and matrix metalloproteinases
(MMPs) are activated in intestinal tissues of patients with active inflammatory bowel …

The multifaceted roles of EGFL7 in cancer and drug resistance

B Heissig, Y Salama, S Takahashi, K Okumura… - Cancers, 2021 - mdpi.com
Simple Summary Cancer growth and metastasis require interactions with the extracellular
matrix (ECM), which is home to many biomolecules that support the formation of new …

Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine …

A Sato, C Nishida, K Sato-Kusubata, M Ishihara… - Leukemia, 2015 - nature.com
The systemic inflammatory response observed during acute graft-versus-host disease
(aGVHD) is driven by proinflammatory cytokines, a 'cytokine storm'. The function of plasmin …

Cancer therapy targeting the fibrinolytic system

B Heissig, S Eiamboonsert, Y Salama… - Advanced drug delivery …, 2016 - Elsevier
The tumor microenvironment is recognized as a key factor in the multiple stages of cancer
progression, mediating local resistance, immune-escape and metastasis. Cancer growth …

The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization

D Zakrzewicz, M Didiasova, A Zakrzewicz… - Biochemical …, 2014 - portlandpress.com
Cell-surface-associated proteolysis plays a crucial role in embryonic development,
monocyte/macrophage recruitment and tumour cell invasion. The glycolytic enzyme ENO-1 …

Sintered anorganic bone graft increases autocrine expression of VEGF, MMP-2 and MMP-9 during repair of critical-size bone defects

CA Rocha, TM Cestari, HA Vidotti, GF de Assis… - Journal of molecular …, 2014 - Springer
This study aimed to evaluate morphometrically the bone formation and
immunohistochemically the expression of vascular endothelial growth factor (VEGF) and …