Streptomyces are attractive microbial cell factories that have industrial capability to produce
a wide array of bioactive secondary metabolites. However, the genetic potential of the …

Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …

Cyclopropane-functionalized hydrocarbons are excellent fuels due their high energy
density. However, the organic synthesis of these molecules is challenging. In this work, we …

Rhodococcus opacus PD630 is a non-model Gram-positive bacterium that possesses
desirable traits for lignocellulosic biomass conversion. In particular, it has a relatively rapid …

Synthetic biology is a logical extension of what has been called recombinant DNA (rDNA)
technology or genetic engineering since the 1970s. As rDNA technology has been the driver …

The rise of antibiotic-resistant bacteria represents a major threat to global health, creating an
urgent need to discover new antibiotics. Natural products derived from the genus …

Prokaryotic cell-free coupled transcription–translation (TX-TL) systems are emerging as a
powerful tool to examine natural product biosynthetic pathways in a test tube. The key …

Streptomyces venezuelae is a promising chassis in synthetic biology for fine chemical and
secondary metabolite pathway engineering. The potential of S. venezuelae could be further …

Microbial production of fuels and commodity chemicals has been performed primarily using
natural or slightly modified enzymes, which inherently limits the types of molecules that can …

Microbial natural products (NPs) are a major source of pharmacological agents. Most NPs
are synthesized from specific biosynthetic gene clusters (BGCs). With the rapid increase of …