At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

Activity has an important role in refining synaptic connectivity during development, in part
through'Hebbian'mechanisms such as long-term potentiation and long-term depression …

Dendritic spines serve as preferential sites of excitatory synaptic connections and are
pleomorphic. To address the structure–function relationship of the dendritic spines, we used …

Synapse regulation exploits the capacity of actin to function as a stable structural component
or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological …

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

In response to activity deprivation, CNS neurons undergo slow adaptive modification of
unitary synaptic transmission. The changes are comparable in degree to those induced by …

Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …

The spatial distribution of proteins and their arrangement within the cellular ultrastructure
regulates the opening of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) …

Changes in the response to release of a single synaptic vesicle have generally been
attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now …

Neurotransmitter is released synchronously and asynchronously following an action
potential. Our recent study indicates that the release sites of these two phases are …