Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …

DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …