The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum
JM Moscarello, MA Penzo - Nature Neuroscience, 2022 - nature.com
In nature, animals display defensive behaviors that reflect the spatiotemporal distance of
threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have …
threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have …
Valence coding in amygdala circuits
M Pignatelli, A Beyeler - Current opinion in behavioral sciences, 2019 - Elsevier
Highlights•Populations of the amygdala complex drive positive and negative
valence.•Valence coding can be defined by neural responses to positive and negative …
valence.•Valence coding can be defined by neural responses to positive and negative …
[HTML][HTML] Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions
It is well known that affective and pleasant touch promotes individual well-being and
facilitates affiliative social communication, although the neural circuit that mediates this …
facilitates affiliative social communication, although the neural circuit that mediates this …
General anesthetics activate a potent central pain-suppression circuit in the amygdala
General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss
of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA …
of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA …
Periaqueductal gray neurons encode the sequential motor program in hunting behavior of mice
H Yu, X Xiang, Z Chen, X Wang, J Dai, X Wang… - Nature …, 2021 - nature.com
Sequential encoding of motor programs is essential for behavior generation. However,
whether it is critical for instinctive behavior is still largely unknown. Mouse hunting behavior …
whether it is critical for instinctive behavior is still largely unknown. Mouse hunting behavior …
Central amygdala micro-circuits mediate fear extinction
Fear extinction is an adaptive process whereby defensive responses are attenuated
following repeated experience of prior fear-related stimuli without harm. The formation of …
following repeated experience of prior fear-related stimuli without harm. The formation of …
A central extended amygdala circuit that modulates anxiety
S Ahrens, MV Wu, A Furlan, GR Hwang… - Journal of …, 2018 - Soc Neuroscience
Both the amygdala and the bed nucleus of the stria terminalis (BNST) have been implicated
in maladaptive anxiety characteristics of anxiety disorders. However, the underlying circuit …
in maladaptive anxiety characteristics of anxiety disorders. However, the underlying circuit …
Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting
The neural substrates for predatory hunting, an evolutionarily conserved appetitive behavior,
remain largely undefined. Photoactivation of zona incerta (ZI) GABAergic neurons strongly …
remain largely undefined. Photoactivation of zona incerta (ZI) GABAergic neurons strongly …
Dorsal tegmental dopamine neurons gate associative learning of fear
F Groessl, T Munsch, S Meis, J Griessner… - Nature …, 2018 - nature.com
Functional neuroanatomy of Pavlovian fear has identified neuronal circuits and synapses
associating conditioned stimuli with aversive events. Hebbian plasticity within these …
associating conditioned stimuli with aversive events. Hebbian plasticity within these …
Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding
The central amygdala (CeA) consists of numerous genetically defined inhibitory neurons
that control defensive and appetitive behaviors including feeding. Transcriptomic signatures …
that control defensive and appetitive behaviors including feeding. Transcriptomic signatures …