Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the
management of various cancers. Different concepts of modification within the adenovirus …

Arnold J. Levine negatively regulated by the adenovirus E1B-55Kd protein and the human
MDM2 protein. In both cases, p53 Department of Molecular Biology amino acid residues 22 …

Cell-matrix interactions have major effects upon phenotypic features such as gene
regulation, cytoskeletal structure, differentiation, and aspects of cell growth control …

In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …

The mechanisms by which the p53 tumor suppressor acts remain incompletely understood.
To gain new insights into p53 biology, we used high-throughput sequencing to analyze …

Background: The p53 tumor suppressor gene is mutated in a large percentage of human
malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit …

Multiple genetic changes occur during the evolution of normal cells into cancer cells. This
evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair …

Although the primary cellular targets of many anticancer agents have been identified, less is
known about the processes leading to the selective cell death of cancer cells or the …

Biologic machines need brakes, and the nature and fidelity of their operation cannot be
unraveled without some prior understanding of how accelerators work. The discoveD] of …

The transcription factor p53 is a vital tumor suppressor. Upon activation by diverse stresses
including oncogene activation, DNA damage, hypoxia and nutrient deprivation, p53 …