[HTML][HTML] Concepts in oncolytic adenovirus therapy
K Mantwill, FG Klein, D Wang, SV Hindupur… - International Journal of …, 2021 - mdpi.com
Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the
management of various cancers. Different concepts of modification within the adenovirus …
management of various cancers. Different concepts of modification within the adenovirus …
[HTML][HTML] p53, the cellular gatekeeper for growth and division
AJ Levine - cell, 1997 - cell.com
Arnold J. Levine negatively regulated by the adenovirus E1B-55Kd protein and the human
MDM2 protein. In both cases, p53 Department of Molecular Biology amino acid residues 22 …
MDM2 protein. In both cases, p53 Department of Molecular Biology amino acid residues 22 …
Disruption of epithelial cell-matrix interactions induces apoptosis
SM Frisch, H Francis - The Journal of cell biology, 1994 - rupress.org
Cell-matrix interactions have major effects upon phenotypic features such as gene
regulation, cytoskeletal structure, differentiation, and aspects of cell growth control …
regulation, cytoskeletal structure, differentiation, and aspects of cell growth control …
Apoptosis in cancer
SW Lowe, AW Lin - Carcinogenesis, 2000 - academic.oup.com
In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …
understanding of cancer biology and cancer genetics. Among the most important of these …
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
The mechanisms by which the p53 tumor suppressor acts remain incompletely understood.
To gain new insights into p53 biology, we used high-throughput sequencing to analyze …
To gain new insights into p53 biology, we used high-throughput sequencing to analyze …
Tumor spectrum analysis in p53-mutant mice
T Jacks, L Remington, BO Williams, EM Schmitt… - Current biology, 1994 - cell.com
Background: The p53 tumor suppressor gene is mutated in a large percentage of human
malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit …
malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit …
Cell cycle control and cancer
LH Hartwell, MB Kastan - Science, 1994 - science.org
Multiple genetic changes occur during the evolution of normal cells into cancer cells. This
evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair …
evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair …
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
SW Lowe, HE Ruley, T Jacks, DE Housman - Cell, 1993 - cell.com
Although the primary cellular targets of many anticancer agents have been identified, less is
known about the processes leading to the selective cell death of cancer cells or the …
known about the processes leading to the selective cell death of cancer cells or the …
[PDF][PDF] Inhibitors of mammalian G1 cyclin-dependent kinases
CJ Sherr, JM Roberts - Genes and development, 1995 - scholar.archive.org
Biologic machines need brakes, and the nature and fidelity of their operation cannot be
unraveled without some prior understanding of how accelerators work. The discoveD] of …
unraveled without some prior understanding of how accelerators work. The discoveD] of …
[HTML][HTML] Deconstructing networks of p53-mediated tumor suppression in vivo
AM Kaiser, LD Attardi - Cell Death & Differentiation, 2018 - nature.com
The transcription factor p53 is a vital tumor suppressor. Upon activation by diverse stresses
including oncogene activation, DNA damage, hypoxia and nutrient deprivation, p53 …
including oncogene activation, DNA damage, hypoxia and nutrient deprivation, p53 …