Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …

Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Endothelial cells (ECs) line the inside of blood vessels and respond to mechanical cues
generated by blood flow. Mechanical stimuli regulate the localization of YAP by reorganizing …

The field of angiogenesis research has primarily focused on the mechanisms of sprouting
angiogenesis. Yet vascular networks formed by vessel sprouting subsequently undergo …

Forces that are associated with blood flow are major determinants of vascular
morphogenesis and physiology. Blood flow is crucial for blood vessel development during …

Human tissues are intricate ensembles of multiple cell types embedded in complex and well-
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …

The low-density lipoprotein receptor–related protein (Lrp)-5 functions as a Wnt coreceptor.
Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass …

Modulation of Tie2 receptor activity by its angiopoietin ligands is crucial for angiogenesis,
blood vessel maturation, and vascular endothelium integrity. It has been proposed that …

As blood flows, the vascular wall is constantly subjected to physical forces, which regulate
important physiological blood vessel responses, as well as being implicated in the …

Angiogenesis inhibitors are receiving increased attention as cancer therapeutics, but little is
known of the cellular effects of these inhibitors on tumor vessels. We sought to determine …