Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion
Fluid and HCO3− secretion is a vital function of all epithelia and is required for the survival of
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …
Cigarette smoke and CFTR: implications in the pathogenesis of COPD
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder
consisting of chronic bronchitis and/or emphysema. COPD patients suffer from chronic …
consisting of chronic bronchitis and/or emphysema. COPD patients suffer from chronic …
Mechanisms of bicarbonate secretion in the pancreatic duct
MC Steward, H Ishiguro, RM Case - Annu. Rev. Physiol., 2005 - annualreviews.org
▪ Abstract In many species the pancreatic duct epithelium secretes HCO3− ions at a
concentration of around 140 mM by a mechanism that is only partially understood. We know …
concentration of around 140 mM by a mechanism that is only partially understood. We know …
ATP as a signaling molecule: the exocrine focus
I Novak - Physiology, 2003 - journals.physiology.org
Why and how do cells release ATP? It is not spilled energy. ATP becomes an extracellular
regulator. Various cellular responses are initiated by purinergic receptors and signaling …
regulator. Various cellular responses are initiated by purinergic receptors and signaling …
Functional anatomy of normal bile ducts
M Strazzabosco, L Fabris - The Anatomical Record: Advances …, 2008 - Wiley Online Library
The biliary tree is a complex network of conduits that begins with the canals of Hering and
progressively merges into a system of interlobular, septal, and major ducts which then …
progressively merges into a system of interlobular, septal, and major ducts which then …
Pathophysiology of cholangiopathies
The diseases of the intrahepatic biliary tree are a large group of potentially evolutive
congenital and acquired liver disorders affecting both the adult and pediatric populations …
congenital and acquired liver disorders affecting both the adult and pediatric populations …
[HTML][HTML] Chloride channelopathies
R Planells-Cases, TJ Jentsch - … et Biophysica Acta (BBA)-Molecular Basis …, 2009 - Elsevier
Channelopathies, defined as diseases that are caused by mutations in genes encoding ion
channels, are associated with a wide variety of symptoms. Impaired chloride transport can …
channels, are associated with a wide variety of symptoms. Impaired chloride transport can …
Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile
N Minagawa, J Nagata, K Shibao, AI Masyuk… - Gastroenterology, 2007 - Elsevier
Background & Aims: Bicarbonate secretion is a primary function of cholangiocytes. Either
adenosine 3′, 5′-cyclic monophosphate (cAMP) or cytosolic Ca2+ can mediate …
adenosine 3′, 5′-cyclic monophosphate (cAMP) or cytosolic Ca2+ can mediate …
Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion
Background & Aims: Cholangiopathies are characterized by impaired cholangiocyte
secretion. Ursodeoxycholic acid (UDCA) is widely used for cholangiopathy treatment, but its …
secretion. Ursodeoxycholic acid (UDCA) is widely used for cholangiopathy treatment, but its …
Purinergic receptors in the endocrine and exocrine pancreas
I Novak - Purinergic signalling, 2008 - Springer
The pancreas is a complex gland performing both endocrine and exocrine functions. In
recent years there has been increasing evidence that both endocrine and exocrine cells …
recent years there has been increasing evidence that both endocrine and exocrine cells …