Highlights•TRIM proteins are E3 ubiquitin ligases that target specific substrates.•TRIM
proteins regulate antiviral cytokine induction or autophagy.•Several TRIM proteins directly …

Abstract Purpose of Review Tripartite motif (TRIM) proteins are a large group of E3 ubiquitin
ligases involved in different cellular functions. Of special interest are their roles in innate …

The worldwide SARS-CoV-2 outbreak poses a serious challenge to human societies and
economies. SARS-CoV-2 proteins orchestrate complex pathogenic mechanisms that …

Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …

Over thirty years have passed since the first description of ubiquitin-positive structures in the
brain of patients suffering from Alzheimer's disease. Meanwhile, the intracellular …

The innate immune system responds rapidly to protect against viral infections, but an
overactive response can cause harmful damage. To avoid this, the response is tightly …

Anatomically modern humans carry many introgressed variants from other hominins in their
genomes. Some of them affect their phenotype and can thus be negatively or positively …

The Tripartite motif (TRIM) protein family, which contains over 80 members in human
sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family. It is implicated …

Porcine epidemic diarrhoea (PED) caused by the porcine epidemic diarrhoea virus (PEDV)
is the most devastating disease in the global pig industry due to its high mortality rate in …

Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of
Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas …