Novel (-)-arctigenin derivatives inhibit signal transducer and activator of transcription 3 phosphorylation and P-glycoprotein function resensitizing multidrug resistant …
KH Yu, CY Kuo, IT Wu, CH Chi, KC Tsai, PC Kuo… - European Journal of …, 2023 - Elsevier
Multidrug resistance (MDR) is considered one of the significant chemotherapy failures of
cancer patients and resulting in tumor recurrence and refractory cancer. The collateral …
cancer patients and resulting in tumor recurrence and refractory cancer. The collateral …
Phloroglucinols with hAChE and α-glucosidase inhibitory activities from the leaves of tropic Rhodomyrtus tomentosa
MY Yu, SN Liu, EE Luo, Q Jin, H Liu, HY Liu, XD Luo… - Phytochemistry, 2022 - Elsevier
Four undescribed phloroglucinol meroterpenoids, rhodotomentodiones A–D, and one
undescribed phloroglucinol dimer, rhodotomentodimer A, were obtained and structurally …
undescribed phloroglucinol dimer, rhodotomentodimer A, were obtained and structurally …
[HTML][HTML] A natural acylphloroglucinol exerts anti-erythroleukemia effects via targeting STAT3 and p38-MAPK, and inhibiting PI3K/AKT/mTOR signaling pathway
JR Song, ZP Niu, K Yang, L Wang, YB Huang… - Biomedicine & …, 2024 - Elsevier
Erythroleukemia, a subtype of acute myeloid leukemia (AML), is a life-threatening
malignancy that affects the blood and bone marrow. Despite the availability of clinical …
malignancy that affects the blood and bone marrow. Despite the availability of clinical …
Multi-omics joint analysis reveals that the Miao medicine Yindanxinnaotong formula attenuates non-alcoholic fatty liver disease
L Huang, Q Rao, C Wang, Y Mou, X Zheng, E Hu… - Phytomedicine, 2024 - Elsevier
Backgroud Non-alcoholic fatty liver disease (NAFLD) is a growing chronic liver disease
worldwide, and no effective agent is approved yet for this condition. Traditional Chinese …
worldwide, and no effective agent is approved yet for this condition. Traditional Chinese …
Integrating UPLC-HR-MS/MS, Network Pharmacology, and Experimental Validation to Uncover the Mechanisms of Jin'gan Capsules against Breast Cancer
J Qiu, Z Zhang, A Hu, P Zhao, X Wei, H Song… - ACS …, 2022 - ACS Publications
In the theory of traditional Chinese medicine (TCM),“liver-qi” stagnation and heat-induced
toxicity represent the main etiologies of breast cancer. Recently, several TCMs with heat …
toxicity represent the main etiologies of breast cancer. Recently, several TCMs with heat …
A Carbon 21 Steroidal Glycoside with Pregnane Skeleton from Cynanchum atratum Bunge Promotes Megakaryocytic and Erythroid Differentiation in Erythroleukemia …
J Yang, C Pan, Y Pan, A Hu, P Zhao, M Chen, H Song… - Pharmaceuticals, 2024 - mdpi.com
Erythroleukemia is a rare form of acute myeloid leukemia (AML). Its molecular pathogenesis
remains vague, and this disease has no specific therapeutic treatments. Previously, our …
remains vague, and this disease has no specific therapeutic treatments. Previously, our …
Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway
Chronic myeloid leukemia (CML) accounts for a major cause of death in adult leukemia
patients due to mutations or other reasons for dysfunction in the ABL proto-oncogene. The …
patients due to mutations or other reasons for dysfunction in the ABL proto-oncogene. The …
Synthetic flavagline derivative 1‐chloroacetylrocaglaol promotes apoptosis in K562 erythroleukemia cells through miR‐17‐92 cluster genes
X Wu, X Yang, KM Varier, Q Rao, J Song… - Archiv der …, 2022 - Wiley Online Library
Chronic myeloid leukemia accounts for human deaths worldwide and could enhance
sevenfold by 2050. Thus, the treatment regimen for this disorder is highly crucial at this time …
sevenfold by 2050. Thus, the treatment regimen for this disorder is highly crucial at this time …