Leucine-rich repeat kinase 2 (LRRK2) is one of the most promising targets for Parkinson's
disease. LRRK2-targeting strategies have primarily focused on type 1 kinase inhibitors …

Introduction Many pathologies, including cancer, have been associated with aberrant
phosphorylation-mediated signaling networks that drive altered cell proliferation, migration …

To facilitate analysis and sharing of mass spectrometry (MS)-based proteomics data, we
created online tools called CURTAIN (https://curtain. proteo. info) and CURTAIN-PTM …

Protein phosphorylation is a ubiquitous post-translational modification controlled by the
opposing activities of protein kinases and phosphatases, which regulate diverse biological …

SGK3 is a PX domain containing protein kinase activated at endosomes downstream of
class 1 and 3 PI3K family members by growth factors and oncogenic mutations. SGK3 plays …

Mutations that increase the protein kinase activity of LRRK2 are one of the most common
causes of familial Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases …

The formation of complexes between Rab11 and its effectors regulates multiple aspects of
membrane trafficking, including recycling and ciliogenesis. WD repeat–containing protein 44 …

Platelet α-granules regulate hemostasis and myriad other physiological processes, but their
biogenesis is unclear. Mutations in only 3 proteins are known to cause α-granule defects …

Reversible protein phosphorylation plays a vital role in many biological processes. In current
phosphoproteomics, targeted enrichment before mass spectrometry (MS) analysis is …

Serum-and glucocorticoid-regulated kinase 3 (Sgk3) is a serine/threonine protein kinase
activated by the phospholipid phosphatidylinositol 3-phosphate (PI3P) downstream of …