Myeloperoxidase as an active disease biomarker: recent biochemical and pathological perspectives
Myeloperoxidase (MPO) belongs to the family of heme-containing peroxidases, produced
mostly from polymorphonuclear neutrophils. The active enzyme (150 kDa) is the product of …
mostly from polymorphonuclear neutrophils. The active enzyme (150 kDa) is the product of …
Hypochlorous acid chemistry in mammalian cells—influence on infection and role in various pathologies
CMC Andrés, JM Pérez de la Lastra, CA Juan… - International journal of …, 2022 - mdpi.com
This review discusses the formation of hypochlorous acid HOCl and the role of reactive
chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO …
chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO …
Pharmacological therapeutics targeting RNA-dependent RNA polymerase, proteinase and spike protein: from mechanistic studies to clinical trials for COVID-19
An outbreak of novel coronavirus-related pneumonia COVID-19, that was identified in
December 2019, has expanded rapidly, with cases now confirmed in more than 211 …
December 2019, has expanded rapidly, with cases now confirmed in more than 211 …
Methods for measuring myeloperoxidase activity toward assessing inhibitor efficacy in living systems
Myeloperoxidase aids in clearance of microbes by generation of peroxidase-mediated
oxidants that kill leukocyte-engulfed pathogens. In this review, we will examine 1) strategies …
oxidants that kill leukocyte-engulfed pathogens. In this review, we will examine 1) strategies …
Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: a new paradigm for drug discovery
Epidemiological results revealed that there is an inverse correlation between high-density
lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease …
lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease …
Luminol Chemiluminescence Reports Photodynamic Therapy‐Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy
RW Davis IV, E Snyder, J Miller, S Carter… - Photochemistry and …, 2019 - Wiley Online Library
Inflammatory cells, most especially neutrophils, can be a necessary component of the
antitumor activity occurring after administration of photodynamic therapy. Generation of …
antitumor activity occurring after administration of photodynamic therapy. Generation of …
Reactive dicarbonyl scavenging effectively reduces MPO-mediated oxidation of HDL and restores PON1 activity
Atheroprotective functions of high-density lipoproteins (HDL) are related to the activity of
HDL-associated enzymes such as paraoxonase 1 (PON1). We examined the impact of …
HDL-associated enzymes such as paraoxonase 1 (PON1). We examined the impact of …
Peptide inhibitor of complement C1 inhibits the peroxidase activity of hemoglobin and myoglobin
PS Hair, KM Cunnion… - International Journal of …, 2017 - Wiley Online Library
Hemoglobin is the natural carrier of oxygen in red blood cells (RBCs). While intracellular
hemoglobin provides life‐sustaining oxygen transport, extracellular free hemoglobin …
hemoglobin provides life‐sustaining oxygen transport, extracellular free hemoglobin …
Synthetic guaiacol derivatives as promising myeloperoxidase inhibitors targeting atherosclerotic cardiovascular disease
Myeloperoxidase (MPO) is known to cause oxidative stress and inflammation leading to
cardiovascular disease (CVD) complications. MPO‐mediated oxidation of lipoproteins leads …
cardiovascular disease (CVD) complications. MPO‐mediated oxidation of lipoproteins leads …
Myeloperoxidase Inhibitory and Antioxidant Activities of (E)-2-Hydroxy-α-aminocinnamic Acids Obtained through Microwave-Assisted Synthesis
A Rivera-Antonio, MC Rosales-Hernández… - Pharmaceuticals, 2021 - mdpi.com
Myeloperoxidase (MPO) is an enzyme present in human neutrophils, whose main role is to
provide defenses against invading pathogens. However, highly reactive oxygen species …
provide defenses against invading pathogens. However, highly reactive oxygen species …