Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
Current status and applications of genome-scale metabolic models
Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction
associations for entire metabolic genes in an organism, and can be simulated to predict …
associations for entire metabolic genes in an organism, and can be simulated to predict …
[HTML][HTML] Recognizing the benefits of pre-/probiotics in metabolic syndrome and type 2 diabetes mellitus considering the influence of akkermansia muciniphila as a key …
Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) are diseases that can be
influenced by the structure of gut microbiota, whose improvement is often neglected in …
influenced by the structure of gut microbiota, whose improvement is often neglected in …
Role of gut microbiota on onset and progression of microvascular complications of type 2 diabetes (T2DM)
Type 2 diabetes mellitus (T2DM) remains one of the most problematic and economic
consumer disorders worldwide, with growing prevalence and incidence. Over the last years …
consumer disorders worldwide, with growing prevalence and incidence. Over the last years …
The critical role of Faecalibacterium prausnitzii in human health: An overview
Faecalibacterium prausnitzii (F. prausnitzii) is one of the most abundant bacterial species in
the colon of healthy human adults and representing more than 5% of the total bacterial …
the colon of healthy human adults and representing more than 5% of the total bacterial …
The relationship between the gut microbiome and metformin as a key for treating type 2 diabetes mellitus
CB Lee, SU Chae, SJ Jo, UM Jerng… - International journal of …, 2021 - mdpi.com
Metformin is the first-line pharmacotherapy for treating type 2 diabetes mellitus (T2DM);
however, its mechanism of modulating glucose metabolism is elusive. Recent advances …
however, its mechanism of modulating glucose metabolism is elusive. Recent advances …
Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson's disease
Parkinson's disease (PD) is the most common progressive neurological disorder
compromising motor functions. However, nonmotor symptoms, such as gastrointestinal (GI) …
compromising motor functions. However, nonmotor symptoms, such as gastrointestinal (GI) …
Modulating the microbiota as a therapeutic intervention for type 2 diabetes
Mounting evidence suggested that the gut microbiota has a significant role in the
metabolism and disease status of the host. In particular, Type 2 Diabetes (T2D), which has a …
metabolism and disease status of the host. In particular, Type 2 Diabetes (T2D), which has a …
Metformin affects gut microbiome composition and function and circulating short-chain fatty acids: a randomized trial
OBJECTIVE To determine the longer-term effects of metformin treatment and behavioral
weight loss on gut microbiota and short-chain fatty acids (SCFAs). RESEARCH DESIGN …
weight loss on gut microbiota and short-chain fatty acids (SCFAs). RESEARCH DESIGN …