Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Microorganisms produce small bioactive compounds as part of their secondary or
specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal …

This study uses three machine learning algorithms including, support vector machine (SVM),
random forest (RF) and gradient boosting machine (GBM) in the appraisal of property prices …

Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …

Microbial secondary metabolites are a potent source of antibiotics and other
pharmaceuticals. Genome mining of their biosynthetic gene clusters has become a key …

Integrating the governing chemistry with the genomics and phenotypes of microbial colonies
has been a “holy grail” in microbiology. This work describes a highly sensitive, broadly …

Bacterial and fungal secondary metabolism is a rich source of novel bioactive compounds
with potential pharmaceutical applications as antibiotics, anti-tumor drugs or cholesterol …

The products of many bacterial non-ribosomal peptide synthetases (NRPS) are highly
important secondary metabolites, including vancomycin and other antibiotics. The ability to …

New bioinformatic tools are needed to analyze the growing volume of DNA sequence data.
This is especially true in the case of secondary metabolite biosynthesis, where the highly …