Targeting voltage-gated calcium channels in neurological and psychiatric diseases
GW Zamponi - Nature reviews Drug discovery, 2016 - nature.com
Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
Sensory processing at ribbon synapses in the retina and the cochlea
T Moser, CP Grabner, F Schmitz - Physiological reviews, 2020 - journals.physiology.org
In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …
function of ribbon synapses which process sensory information in the eye and ear. This …
Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses
E Eggermann, I Bucurenciu, SP Goswami… - Nature Reviews …, 2012 - nature.com
The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse
The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal
precision and maintains a high level of neurotransmitter release. However, the molecular …
precision and maintains a high level of neurotransmitter release. However, the molecular …
Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness
SM Baig, A Koschak, A Lieb, M Gebhart… - Nature …, 2011 - nature.com
Deafness is genetically very heterogeneous and forms part of several syndromes. So far,
delayed rectifier potassium channels have been linked to human deafness associated with …
delayed rectifier potassium channels have been linked to human deafness associated with …
Diversity matters—extending sound intensity coding by inner hair cells via heterogeneous synapses
Our sense of hearing enables the processing of stimuli that differ in sound pressure by more
than six orders of magnitude. How to process a wide range of stimulus intensities with …
than six orders of magnitude. How to process a wide range of stimulus intensities with …
The diverse roles of ribbon synapses in sensory neurotransmission
G Matthews, P Fuchs - Nature Reviews Neuroscience, 2010 - nature.com
Sensory synapses of the visual and auditory systems must faithfully encode a wide dynamic
range of graded signals, and must be capable of sustained transmitter release over long …
range of graded signals, and must be capable of sustained transmitter release over long …
Tuning of synapse number, structure and function in the cochlea
AC Meyer, T Frank, D Khimich, G Hoch, D Riedel… - Nature …, 2009 - nature.com
Cochlear inner hair cells (IHCs) transmit acoustic information to spiral ganglion neurons
through ribbon synapses. Here we have used morphological and physiological techniques …
through ribbon synapses. Here we have used morphological and physiological techniques …
Bassoon and the synaptic ribbon organize Ca2+ channels and vesicles to add release sites and promote refilling
At the presynaptic active zone, Ca 2+ influx triggers fusion of synaptic vesicles. It is not well
understood how Ca 2+ channel clustering and synaptic vesicle docking are organized …
understood how Ca 2+ channel clustering and synaptic vesicle docking are organized …
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells
T Pangršič, L Lasarow, K Reuter, H Takago… - Nature …, 2010 - nature.com
Inner hair cell ribbon synapses indefatigably transmit acoustic information. The proteins
mediating their fast vesicle replenishment (hundreds of vesicles per s) are unknown. We …
mediating their fast vesicle replenishment (hundreds of vesicles per s) are unknown. We …