Bilirubin-induced neurological damage: current and emerging iPSC-derived brain organoid models

AI Pranty, S Shumka, J Adjaye - Cells, 2022 - mdpi.com
Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades,
yet the molecular mechanisms at the core of this damage remain largely unknown …

Global trends in clinical trials involving pluripotent stem cells: a systematic multi-database analysis

J Deinsberger, D Reisinger, B Weber - NPJ Regenerative medicine, 2020 - nature.com
Pluripotent stem cells (PSCs) hold great potential for novel therapeutic approaches to
regenerate or replace functionally impaired tissues. Since the introduction of the induced …

Mesenchymal stem cells and tissue bioengineering applications in sheep as ideal model

TDPTP Muniz, MC Rossi… - Stem Cells …, 2024 - Wiley Online Library
The most common technologies in tissue engineering include growth factor therapies; metal
implants, such as titanium; 3D bioprinting; nanoimprinting for ceramic/polymer scaffolds; and …

Free Bilirubin Induces Neuro-Inflammation in an Induced Pluripotent Stem Cell-Derived Cortical Organoid Model of Crigler-Najjar Syndrome

AI Pranty, W Wruck, J Adjaye - Cells, 2023 - mdpi.com
Bilirubin-induced neurological damage (BIND), which might progress to kernicterus, occurs
as a consequence of defects in the bilirubin conjugation machinery, thus enabling albumin …

Induced pluripotency: a powerful tool for in vitro modeling

R Zahumenska, V Nosal, M Smolar… - International Journal of …, 2020 - mdpi.com
One of the greatest breakthroughs of regenerative medicine in this century was the
discovery of induced pluripotent stem cell (iPSC) technology in 2006 by Shinya Yamanaka …

[HTML][HTML] An Overview of Multiple Sclerosis In Vitro Models

J Czpakowska, M Kałuża, P Szpakowski… - International Journal of …, 2024 - mdpi.com
Multiple sclerosis (MS) still poses a challenge in terms of complex etiology, not fully effective
methods of treatment, and lack of healing agents. This neurodegenerative condition …

Age-associated loss in renal Nestin-positive progenitor cells

MI Buyan, NV Andrianova, VA Popkov… - International Journal of …, 2022 - mdpi.com
The decrease in the number of resident progenitor cells with age was shown for several
organs. Such a loss is associated with a decline in regenerative capacity and a greater …

The relationship between mesenchymal stem cells and tumor dormancy

L Zhao, K Zhang, H He, Y Yang, W Li… - Frontiers in cell and …, 2021 - frontiersin.org
Tumor dormancy, a state of tumor, is clinically undetectable and the outgrowth of dormant
tumor cells into overt metastases is responsible for cancer-associated deaths. However, the …

A comparative study of cell culture conditions during conversion from primed to naive human pluripotent stem cells

I Romayor, L Herrera, M Burón, M Martin-Inaraja… - Biomedicines, 2022 - mdpi.com
The successful reprogramming of human somatic cells into induced pluripotent stem cells
(hiPSCs) represented a turning point in the stem cell research field, owing to their ability to …

Pharmacoepigenetic processors: epigenetic drugs, drug resistance, toxicoepigenetics, and nutriepigenetics

R Cacabelos, JC Carril, A Sanmartín, P Cacabelos - Pharmacoepigenetics, 2019 - Elsevier
The pharmacoepigenetic apparatus is integrated by gene clusters of different categories,
including (i) pathogenic genes involved in disease pathogenesis,(ii) mechanistic genes …