Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

This study examined the effects of resistance training on muscle quality, muscle growth
factors, and functional fitness in older adult women with sarcopenia. Twenty-two older adult …

Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

Skeletal muscle plays important roles in normal biological activities and whole-body energy
homeostasis in humans. The growth and development of skeletal muscle also directly …

Exercise, in the form of endurance or resistance training, leads to specific molecular and
cellular adaptions not only in skeletal muscles, but also in many other organs such as the …

Different forms of physical activity—endurance, resistance or dynamic power—stimulate
cytokine release from various tissues to the bloodstream. Receptors for exercise-induced …

The production of reactive oxygen species (ROS) by NADPH oxidase (NOX) 2 has been
linked to both insulin resistance and exercise training adaptations in skeletal muscle. This …

Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular
functions, including actin cytoskeleton remodeling and vesicle traffic. Traditionally, Rho …