Snake venoms in drug discovery: Valuable therapeutic tools for life saving

T Mohamed Abd El-Aziz, AG Soares, JD Stockand - Toxins, 2019 - mdpi.com
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …

Snake venoms and the hemostatic system

FS Markland - Toxicon, 1998 - Elsevier
Snake venoms are complex mixtures containing many different biologically active proteins
and peptides. A number of these proteins interact with components of the human hemostatic …

[图书][B] Handbook of venoms and toxins of reptiles

SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

Anticoagulant proteins from snake venoms: structure, function and mechanism

RM Kini - Biochemical Journal, 2006 - portlandpress.com
Over the last several decades, research on snake venom toxins has provided not only new
tools to decipher molecular details of various physiological processes, but also inspiration to …

Protein complexes in snake venom

R Doley, RM Kini - Cellular and molecular life sciences, 2009 - Springer
Snake venom contains mixture of bioactive proteins and polypeptides. Most of these
proteins and polypeptides exist as monomers, but some of them form complexes in the …

Bleeding and Thrombosis: Insights into Pathophysiology of Bothrops Venom-Related Hemostasis Disorders

S Larréché, JP Chippaux, L Chevillard… - International Journal of …, 2021 - mdpi.com
Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of
clinical and biological syndromes including local and systemic bleeding, incoagulability …

[HTML][HTML] Snake venoms and hemostasis

Q Lu, JM Clemetson, KJ Clemetson - Journal of Thrombosis and …, 2005 - Elsevier
Snake venoms are complex mixtures of biologically active proteins and peptides. Many of
them affect hemostasis by activating or inhibiting coagulant factors or platelets, or by …

Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome

DD Almeida, VL Viala, PG Nachtigall… - Proceedings of the …, 2021 - National Acad Sciences
Venom is a key adaptive innovation in snakes, and how nonvenom genes were co-opted to
become part of the toxin arsenal is a significant evolutionary question. While this process …

Structures and functions of snake venom CLPs (C-type lectin-like proteins) with anticoagulant-, procoagulant-, and platelet-modulating activities

T Morita - Toxicon, 2005 - Elsevier
C-type lectin-like proteins (CLPs) have a variety of biological activities, including
anticoagulant-and platelet-modulating activities but have no lectin activity. CLPs are made …

Identification of glycyrrhizin as a thrombin inhibitor

I Mauricio, B Francischetti, RQ Monteiro… - Biochemical and …, 1997 - Elsevier
Glycyrrhizin (GL), an anti-inflammatory compound isolated fromGlycyrrhiza glabra, was
identified as a new thrombin inhibitor:(a) It prolonged plasma recalcification and thrombin …