Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

Proteogenomic identification of translated small open reading frames has revealed
thousands of previously unannotated, largely uncharacterized microproteins, or …

Metazoan development depends on the accurate execution of differentiation programs that
allow pluripotent stem cells to adopt specific fates. Differentiation requires changes to …

Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in
yeast have established some of the biological principles of ribosome biogenesis, many of …

Patients with physical findings suggestive of Treacher Collins syndrome (TCS) or
mandibulofacial dysostosis (MFD) and macrocytic anemia diagnostic of Diamond–Blackfan …

Disruptions in ribosomal biogenesis would be expected to have global and in fact lethal
effects on a developing organism. However, mutations in ribosomal protein genes have …

Transcription of the ribosomal RNA genes by the dedicated RNA polymerase I enzyme and
subsequent processing of the ribosomal RNA are fundamental control steps in the synthesis …