Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy

G Sloan, D Selvarajah, S Tesfaye - Nature Reviews Endocrinology, 2021 - nature.com
Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Mechanisms of diabetic complications

JM Forbes, ME Cooper - Physiological reviews, 2013 - journals.physiology.org
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy

S Tesfaye, D Selvarajah - Diabetes/metabolism research and …, 2012 - Wiley Online Library
Diabetic peripheral neuropathy (DPN) affects up to 50% of patients with diabetes and is a
major cause of morbidity and increased mortality. Its clinical manifestations include painful …

New perspective in diabetic neuropathy: from the periphery to the brain, a call for early detection, and precision medicine

H Yang, G Sloan, Y Ye, S Wang, B Duan… - Frontiers in …, 2020 - frontiersin.org
Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes
mellitus. It leads to distressing and expensive clinical sequelae such as foot ulceration, leg …

Painful and painless diabetic neuropathies: what is the difference?

P Shillo, G Sloan, M Greig, L Hunt, D Selvarajah… - Current diabetes …, 2019 - Springer
Abstract Purpose of Review The prevalence of diabetes mellitus and its chronic
complications are increasing to epidemic proportions. This will unfortunately result in …

Diabetic neuropathy and neuropathic pain: a (con) fusion of pathogenic mechanisms?

NA Calcutt - Pain, 2020 - journals.lww.com
Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

A new look at painful diabetic neuropathy

G Sloan, P Shillo, D Selvarajah, J Wu… - Diabetes research and …, 2018 - Elsevier
The prevalence of diabetes mellitus and its chronic complications continue to increase
alarmingly. Consequently, the massive expenditure on diabetic distal symmetrical …

Spinal cord stimulation and pain relief in painful diabetic peripheral neuropathy: a prospective two-center randomized controlled trial

R Slangen, NC Schaper, CG Faber, EA Joosten… - Diabetes …, 2014 - Am Diabetes Assoc
OBJECTIVE Painful diabetic peripheral neuropathy (PDPN) is a common complication of
diabetes mellitus. Unfortunately, pharmacological treatment is often partially effective or …

Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options

A Veves, M Backonja, RA Malik - Pain medicine, 2008 - academic.oup.com
Objective. To facilitate the clinician's understanding of the basis and treatment of painful
diabetic neuropathy (PDN). Background. PDN is one of several clinical syndromes in …

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

NA Calcutt, ME Cooper, TS Kern… - Nature Reviews Drug …, 2009 - nature.com
Long-term diabetes increases the likelihood of developing secondary damage to numerous
systems, and these complications represent a substantial cause of morbidity and mortality …