Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Caspases are a family of conserved cysteine proteases that play key roles in programmed
cell death and inflammation. In multicellular organisms, caspases are activated via …

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory
form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The …

Inflammasomes are molecular platforms that assemble upon sensing various intracellular
stimuli. Inflammasome assembly leads to activation of caspase 1, thereby promoting the …

Cell death is central to development, organismal homeostasis, and immune responses. The
cell death field has experienced tremendous progress by delineating the molecular …

PANoptosis is a newly identified type of regulated cell death that consists of pyroptosis,
apoptosis, and necroptosis, which simultaneously occur during the pathophysiological …

Highlights•The NLRP3, NLRC4, and pyrin inflammasomes are regulated by post-
translational modifications.•The Dhx9-NLRP9b inflammasome recognizing viral dsRNA was …

Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …

Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …

Amyloid β-protein (Aβ) is reported to activate NLRP3 inflammasomes and drive pyroptosis,
which is subsequently involved in the pathogenesis of neurodegenerative diseases, such as …