The Philadelphia negative myeloproliferative neoplasms (MPN) compromise a
heterogeneous group of clonal myeloid stem cell disorders comprising polycythaemia vera …

Platelets have long been known to play important roles beyond hemostasis and thrombosis.
Now recognized as a bona fide mediator of malignant disease, platelets influence various …

Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …

Some cancers originate from a single mutation event in a single cell. Blood cancers known
as myeloproliferative neoplasms (MPNs) are thought to originate when a driver mutation is …

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells
(HSCs), leading to clonal haematopoiesis. These lesions are precursors for blood cancers …

Extensively revised, comprehensive content from leading global contributors ensures that
Hematology, 8th Edition, remains your# 1 choice for expert guidance in all areas of this …

BACKGROUND. Although aberrant glycosylation is recognized as a hallmark of cancer,
glycosylation in clinical breast cancer (BC) metastasis has not yet been studied. While …

A lack of models that recapitulate the complexity of human bone marrow has hampered
mechanistic studies of normal and malignant hematopoiesis and the validation of novel …

Human hematopoiesis is a dynamic process that starts in utero 18–21 days post-conception.
Understanding the site-and stage-specific variation in hematopoiesis is important if we are to …

Myelofibrosis (MF) is a progressive chronic myeloproliferative neoplasm characterized by
hyperactivation of JAK/STAT signaling and dysregulation of the transcription factor GATA1 in …