Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

Biomaterials, biomedical devices and engineered cell grafts can be implanted to restitute
tissue anatomy and function. Such implants can either integrate physiologically, with no or …

Methods Pancreases were collected from chloroquine-injected and non-injected non-obese
diabetes-resistant (NOR) and non-obese diabetic (NOD) mice. Age-and BMI-matched …

Background And Aims Destroying visceral sensory nerves impacts pancreatic islet function,
glucose metabolism, and diabetes onset, but how islet endocrine cells interact with sensory …

Abstract The dynamin-like GTPases Mitofusin 1 and 2 (Mfn1 and Mfn2) are essential for
mitochondrial function, which has been principally attributed to their regulation of …

Insulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …

Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …

Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …

What you see is what you get—imaging techniques have long been essential for
visualization and understanding of tissue development, homeostasis, and regeneration …

The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized
insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging …