Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The
understanding of HIV-1 pathogenesis is essentiell to develop and maintain antiretroviral …

Regulation of the expression of the human immunodeficiency virus (HIV) genome is
accomplished in large part by controlling transcription elongation. The viral protein Tat …

HIV-1 TAR RNA is the binding site of the viral protein Tat, the trans-activator of the HIV-1
LTR. It is present at the 5'end of all HIV-1 spliced and unspliced mRNAs in the nucleus as …

It is generally acknowledged that the Tat protein has a pivotal role in HIV-1 replication
because it stimulates transcription from the viral long terminal repeat (LTR) promoter by …

ABSTRACT RNA binding proteins recognize RNA targets in a sequence specific manner.
Apart from the sequence, the secondary structure context of the binding site also affects the …

Promoter-proximal pausing by RNA polymerase II (Pol II) is a key regulatory step in human
immunodeficiency virus-1 (HIV-1) transcription and thus in the reversal of HIV latency. By …

We have previously shown that clusters of guanine quadruplex (G4) structures can form in
the human herpes simplex-1 (HSV-1) genome. Here we used immunofluorescence and …

ABSTRACT A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying
and eradicating persistent reservoirs of replication-competent provirus. Long noncoding …

With the increasing interest of RNAs in regulating a range of cell biological processes, very
little is known about the structure of RNAs in tissue culture cells. We focused on the 5 …