An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

The current gold standard to reduce non-specific cellular uptake of drug delivery vehicles is
by covalent attachment of poly (ethylene glycol)(PEG). It is thought that PEG can reduce …

N 6-methyladenosine (m6A) is the most abundant epitranscriptome modification in
mammalian mRNA. Recent years have seen substantial progress in m6A epitranscriptomics …

Tumors initiate by mutations in cancer cells, and progress through interactions of the cancer
cells with non-malignant cells of the tumor microenvironment. Major players in the tumor …

Cancer-associated fibroblasts (CAFs) are highly prominent in breast tumors, but their
functional heterogeneity and origin are still largely unresolved. We report that bone marrow …

The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer that typically
demonstrates resistance to chemotherapy. Tumor-associated macrophages (TAMs) are …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is largely refractory to
available treatments. Identifying key pathways associated with disease aggressiveness and …

Chemotherapy has been explored as a treatment option for metastatic prostate cancer since
the early 1980s. Docetaxel, a taxane chemotherapeutic, was approved for the treatment of …