Epithelial–mesenchymal interactions play pivotal roles in the morphogenesis of many
organs and various types of appendages. During hair follicle development, extensive …

A growing body of evidence indicates that the epithelial-specific growth factors keratinocyte
growth factor (KGF), fibroblast growth factor (FGF)-10, and hepatocyte growth factor (HGF) …

Glypicans are a family of glycosylphosphatidylinositol-anchored cell surface heparan sulfate
proteoglycans implicated in the control of cellular growth and differentiation. Here we show …

Keratinocyte growth factor (KGF) is a paracrine-acting, epithelial mitogen produced by cells
of mesenchymal origin. It is a member of the fibroblast growth factor (FGF) family, and acts …

Over the past decade, the glycosaminoglycans heparin and heparan sulfate have been
shown to bind and regulate the activities of many proteins. Established techniques have …

Human basement membrane heparan sulfate proteoglycan (HSPG) perlecan binds and
activates fibroblast growth factor (FGF)-2 through its heparan sulfate (HS) chains. Here we …

FGF-7 is induced after injury and induces the proliferation of keratinocytes. Like most
members of the FGF family, the activity of FGF-7 is strongly influenced by binding to heparin …

Heparan sulfates (HS) play an important role in the control of cell growth and differentiation
by virtue of their ability to modulate the activities of heparin-binding growth factors, an issue …

Abstract Glypican-3 (gpc3) is the gene responsible for Simpson-Golabi-Behmel overgrowth
syndrome. Previously, we have shown that GPC3 is overexpressed in hepatocellular …

Human papillomaviruses (HPVs) have previously been shown to adsorb to cultured cells via
membrane-associated heparan sulfate (HS) and α6 integrin. We demonstrate that cultured …