Over the past 15 years, investigators have shown that T lymphocytes can recognize not only
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …

For decades, proteins were thought to be the sole or at least the dominant source of
antigens for T cells. Studies in the 1990s demonstrated that CD 1 proteins and …

Inflammatory skin conditions are increasingly recognised as being associated with systemic
inflammation. The mechanisms connecting the cutaneous and systemic disease are not well …

Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. The
effects of DCs on adaptive immune responses depend partly on functional specialization of …

Atopic dermatitis is a common pruritic skin disease in which barrier dysfunction and
cutaneous inflammation contribute to pathogenesis. Mechanisms underlying the associated …

Abstract Mycobacterium bovis bacille Calmette-Guérin (BCG) prevents extrapulmonary
tuberculosis (TB) and death among infants but fails to consistently and sufficiently prevent …

The now-famous term “restriction” derived from experiments in which T cells from Donor A
failed to recognize Ags presented by cells from Donor B. Restriction results from interdonor …

Highlights•Human CD1a, CD1b, CD1c, and CD1d use distinct pathways for trafficking and
antigen capture.•CD1a, CD1b and CD1c have inducible expression, yet upstream genetic …

The MR1 antigen-presenting system is conserved among mammals and enables T cells to
recognize small molecules produced by bacterial pathogens, including Mycobacterium …

Dendritic cells (DCs) represent a functionally diverse and flexible population of rare cells
with the unique capability of binding, internalizing and detecting various microorganisms …