Neurochemical mechanisms of the defensive behavior in the dorsal midbrain

ML Brandão, VZ Anseloni, JE Pandossio… - Neuroscience & …, 1999 - Elsevier
Some regions in the mesencephalon, such as dorsal periaqueductal gray, inferior colliculus
and deep layers of superior colliculus have been grouped together as a continuos strip of …

Neural substrate of defensive behavior in the midbrain tectum

ML Brandão, SH Cardoso, LL Melo, V Motta… - Neuroscience & …, 1994 - Elsevier
It has been shown that the gradual increase in the intensity of electrical stimulation of the
dorsal periaqueductal gray (DPAG), deep layers of the superior colliculus (DLSC) and …

The relevance of neuronal substrates of defense in the midbrain tectum to anxiety and stress: empirical and conceptual considerations

ML Brandão, AC Troncoso, MA de Souza Silva… - European journal of …, 2003 - Elsevier
The medial hypothalamus, amygdala, and dorsal periaqueductal gray constitute the main
neural substrates for the integration of aversive states in the brain. More recently, some …

Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the …

NC Coimbra, R De Oliveira, RL Freitas, SJ Ribeiro… - Experimental …, 2006 - Elsevier
Deep layers of the superior colliculus, the dorsal periaqueductal gray matter and the inferior
colliculus are midbrain structures involved in the generation of defensive behavior and fear …

Opioid neurotransmission modulates defensive behavior and fear-induced antinociception in dangerous environments

NC Coimbra, F Calvo, RC Almada, RL Freitas… - Neuroscience, 2017 - Elsevier
The effects of endogenous opioid peptide antagonists on panic-related responses are
controversial. Using elevated mazes and a prey-versus-predator paradigm, we investigated …

Defensive and emotional behavior modulation by serotonin in the periaqueductal gray

P Vázquez-León, A Miranda-Páez… - Cellular and Molecular …, 2023 - Springer
Abstract Serotonin 5-hydroxytryptamine (5-HT) is a key neurotransmitter for the modulation
and/or regulation of numerous physiological processes and psychiatric disorders (eg …

Effects of 5-HT2 receptors blockade on fear-induced analgesia elicited by electrical stimulation of the deep layers of the superior colliculus and dorsal periaqueductal …

NC Coimbra, ML Brandão - Behavioural brain research, 1997 - Elsevier
The deep layers of the superior colliculus (DLSC) and the dorsal periaqueductal gray matter
(DPAG) have been implicated in the control of defensive-like behaviors. Electrical and …

Critical neuropsychobiological analysis of panic attack-and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex …

NC Coimbra, T Paschoalin-Maurin, GS Bassi… - Brazilian Journal of …, 2017 - SciELO Brasil
Objective: To compare prey and snake paradigms performed in complex environments to
the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack-and …

Recruitment of striatonigral disinhibitory and nigrotectal inhibitory GABA ergic pathways during the organization of defensive behavior by mice in a dangerous …

RC Almada, NC Coimbra - Synapse, 2015 - Wiley Online Library
The neuropsychopharmacological basis of fear‐or panic‐related behavior has been the
focus of several studies. Some mesencephalic tectum (MT) structures, such as the superior …

Effects of acute and chronic fluoxetine and diazepam on freezing behavior induced by electrical stimulation of dorsolateral and lateral columns of the periaqueductal …

KG Borelli, MJ Nobre, ML Brandão… - Pharmacology …, 2004 - Elsevier
The defensive responses induced by electrical stimulation of the dorsal periaqueductal gray
matter (dPAG) of the rat have been proposed as a model of panic attacks in humans. In the …