Natural products are mainly secondary metabolites produced by plants, microorganisms,
and animals, which are still abundant in modern drug discovery. Terpenoids are the most …

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder which is associated
with the dysregulation of autoimmune response. In recent years, early diagnosis, aggressive …

Triptolide (TPL) is an active component derived from Tripterygium wilfordii Hook F (TwHF)
with therapeutic potential for rheumatoid arthritis (RA). However, the underlying mechanism …

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by
autoimmunity, synovial inflammation and joint destruction. Pannus formation in the synovial …

Rheumatoid arthritis (RA) is a systemic and autoimmune disease that is mainly featured
abnormal fibroblast-like synoviocyte (FLS) proliferation and inflammatory cell infiltration …

Secreted frizzled-related protein 1 (SFRP1) is a member of secretory glycoprotein SFRP
family. As a primitive gene regulating cell growth, development and transformation, SFRP1 …

Rheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on
joint lesions with an extremely high disability and deformity rate. Several drugs have been …

Rheumatoid arthritis (RA) is a systemic chronic autoinflammatory disease, and the synovial
hyperplasia, pannus formation, articular cartilage damage and bone matrix destruction …

Rheumatoid arthritis (RA) is an autoimmune disease accompanied with serious symptoms,
such as joint destruction and chronic synovitis. Though many anti-RA drugs could improve …

Precise expression and regulation of genes in the immune system is important for organisms
to produce strong immunity towards pathogens and limit autoimmunity. In recent years, an …