The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
JW Vardiman, J Thiele, DA Arber… - Blood, The Journal …, 2009 - ashpublications.org
Recently the World Health Organization (WHO), in collaboration with the European
Association for Haematopathology and the Society for Hematopathology, published a …
Association for Haematopathology and the Society for Hematopathology, published a …
The prenatal origins of cancer
GM Marshall, DR Carter, BB Cheung, T Liu… - Nature Reviews …, 2014 - nature.com
The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …
cells has a long history. Recent research has strengthened the links between driver …
The landscape of somatic mutations in Down syndrome–related myeloid disorders
Transient abnormal myelopoiesis (TAM) is a myeloid proliferation resembling acute
megakaryoblastic leukemia (AMKL), mostly affecting perinatal infants with Down syndrome …
megakaryoblastic leukemia (AMKL), mostly affecting perinatal infants with Down syndrome …
GATA factor mutations in hematologic disease
JD Crispino, MS Horwitz - Blood, The Journal of the American …, 2017 - ashpublications.org
GATA family proteins play essential roles in development of many cell types, including
hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3 …
hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3 …
The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis
J Tober, A Koniski, KE McGrath, R Vemishetti… - Blood, 2007 - ashpublications.org
In the adult, platelets are derived from unipotential megakaryocyte colony-forming cells (Meg-
CFCs) that arise from bipotential megakaryocyte/erythroid progenitors (MEPs). To better …
CFCs) that arise from bipotential megakaryocyte/erythroid progenitors (MEPs). To better …
Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971
Transient myeloproliferative disorder (TMD), restricted to newborns with trisomy 21, is a
megakaryocytic leukemia that although lethal in some is distinguished by its spontaneous …
megakaryocytic leukemia that although lethal in some is distinguished by its spontaneous …
Transient abnormal myelopoiesis and AML in Down syndrome: an update
N Bhatnagar, L Nizery, O Tunstall, P Vyas… - Current hematologic …, 2016 - Springer
Children with constitutional trisomy 21 (Down syndrome (DS)) have a unique predisposition
to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a …
to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a …
GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia
I Roberts, K Alford, G Hall, G Juban… - Blood, The Journal …, 2013 - ashpublications.org
Transient abnormal myelopoiesis (TAM), a preleukemic disorder unique to neonates with
Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS) …
Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS) …
Treatment and prognostic impact of transient leukemia in neonates with Down syndrome
JH Klusmann, U Creutzig… - Blood, The Journal …, 2008 - ashpublications.org
Approximately 10% of the neonates with Down syndrome (DS) exhibit a unique transient
leukemia (TL). Though TL resolves spontaneously in most patients, early death and …
leukemia (TL). Though TL resolves spontaneously in most patients, early death and …
Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome
Children with Down syndrome (DS) show a spectrum of clinical anomalies, including
cognitive impairment, cardiac malformations, and craniofacial dysmorphy. Moreover …
cognitive impairment, cardiac malformations, and craniofacial dysmorphy. Moreover …