The chronology and history of characterizing the aromatic hydrocarbon [Ah] battery is
reviewed. This battery represents the Ah receptor (AHR)-mediated control of at least six, and …

Hypertyrosinemia encompasses several entities, of which tyrosinemia type I (or hepatorenal
tyrosinemia, HT1) results in the most extensive clinical and pathological manifestations …

Abstract Analysis of off-target editing is an important aspect of the development of safe
nuclease-based genome editing therapeutics. in vivo assessment of nuclease off-target …

Hereditary tyrosinemia type Ⅰ (HT1) is a severe autosomal recessive inherited metabolic
disease, which can result in severe damage of liver and kidney. Photoacoustic imaging (PAI) …

Rare diseases are frequently life‐threatening or chronically debilitating and the impact on
the quality of life of affected patients and their family members is thus significant. However …

The topic of this review is hepatorenal tyrosinemia (hereditary tyrosinemia type 1 [HT1], or
fumarylacetoacetate hydrolase deficiency; OMIM# 276700). HT1 is the most serious and …

Abstract Hereditary tyrosinaemia type 1 (HT-1) is a rare genetic disease caused by
mutations in the gene for the enzyme fumarylacetoacetase. It usually presents with liver …

Patients suffering from the metabolic disease hereditary tyrosinemia type I (HT1), caused by
fumarylacetoacetate hydrolase deficiency, have a high risk of developing liver cancer. We …

It is well recognized that many metabolic enzymes play essential roles in cancer cells in
producing building blocks such as nucleotides, which are required in greater amounts due …

In inborn errors of metabolism, such as amino acid breakdown disorders, loss of function
mutations in metabolic enzymes within the catabolism pathway lead to an accumulation of …