Detection of circulating tumor DNAs (ctDNAs) in cancer patients is an important component
of cancer precision medicine ctDNAs. Compared to the traditional physical and biochemical …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic
basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent …

Background & Aims Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol
biosynthesis, is suggested as a proto-oncogene. Paradoxically, SQLE is degraded by …

Hepatocellular carcinoma (HCC) is the major primary malignant tumor in the human liver,
but the molecular changes leading to liver cell transformation remain largely unknown. The …

Aberrant activation of the canonical WNT/β-catenin pathway occurs in almost all colorectal
cancers and contributes to their growth, invasion and survival,. Although dysregulated β …

We leveraged a human gut-on-a-chip (Gut Chip) microdevice that enables independent
control of fluid flow and mechanical deformations to explore how physical cues and …

Streptococcus gallolyticus subsp. gallolyticus (Sg) has long been known to have a strong
association with colorectal cancer (CRC). This knowledge has important clinical …

MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known
as to whether it represents a bystander event or actually drives tumor progression in vivo …

The Wnt pathway controls cell fate during embryonic development. It also persists as a key
regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational …