The phenomenon and rationale of marked dependence of drug concentration on blood sampling site: implications in pharmacokinetics, pharmacodynamics …

WL Chiou - Clinical pharmacokinetics, 1989 - Springer
At least 42 compounds have been reported to exhibit significant or marked blood sampling
site dependence in concentration, after dosing in humans and animals. The very high …

Comparison of the Akaike Information Criterion, the Schwarz criterion and the F test as guides to model selection

TM Ludden, SL Beal, LB Sheiner - Journal of pharmacokinetics and …, 1994 - Springer
In pharmacokinetic data analysis, it is frequently necessary to select the number of
exponential terms in a polyexponential expression used to describe the concentration-time …

Gliadin nanoparticles as carriers for the oral administration of lipophilic drugs. Relationships between bioadhesion and pharmacokinetics

MA Arangoa, MA Campanero, MJ Renedo… - Pharmaceutical …, 2001 - Springer
Purpose. The aim of this work was to evaluate the bioadhesive properties of non-hardened
gliadin nanoparticles (NPs) and cross-linked gliadin nanoparticles (CL-NP) in the carbazole …

Mathematical models as tools to predict the release kinetic of fluorescein from lyotropic colloidal liquid crystals

D Paolino, A Tudose, C Celia, L Di Marzio, F Cilurzo… - Materials, 2019 - mdpi.com
In this study, we investigated the release kinetic of fluorescein from colloidal liquid crystals
made from monoglyceride and different non-ionic surfactants. The crystals were …

Learning methods for structural damage detection via entropy‐based sensors selection

F Smarra, J Tjen, A D'Innocenzo - International Journal of …, 2022 - Wiley Online Library
In this article the problem of data‐driven structural damage detection is considered
exploiting historical data collected from a structure. First, a novel technique based on …

Pharmacokinetics of glibenclamide and its metabolites in diabetic patients with impaired renal function

A Jönsson, T Rydberg, G Sterner… - European journal of clinical …, 1998 - Springer
Abstract Background: Glibenclamide (Gb) may provoke long-lasting hypoglycaemic
reactions, and one of the known risk factors is impaired renal function. We have …

Galanthamine: pharmacokinetics, tissue distribution and cholinesterase inhibition in brain of mice

U Bickel, T Thomsen, JP Fischer, W Weber, H Kewitz - Neuropharmacology, 1991 - Elsevier
Galanthamine was determined in plasma and tissue extracts of mice, after the application of
4, 6 and 8 mg/kg (iV), by reverse phase HPLC, with fluorescence detection. A biexponential …

Pharmacokinetics of imipenem-cilastatin in critically ill patients undergoing continuous venovenous hemofiltration

I Tegeder, F Bremer, R Oelkers, H Schobel… - Antimicrobial agents …, 1997 - Am Soc Microbiol
The pharmacokinetics of imipenem-cilastatin were investigated in 12 critically ill patients
with acute renal failure (ARF) managed by continuous veno-venous hemofiltration (CVVH) …

The pharmacokinetics and pharmacodynamics of recombinant human erythropoietin in haemodialysis patients.

J Brockmöller, J Köchling, W Weber… - British journal of …, 1992 - ncbi.nlm.nih.gov
The pharmacokinetics of and therapeutic response to recombinant human erythropoietin
(rcEPO) were studied in 12 patients under chronic haemodialysis on a thrice weekly …

Comparison of the kinetics of glyburide and its active metabolites in humans

T Rydberg, A Jönsson… - Journal of clinical …, 1995 - Wiley Online Library
The pharmacokinetics of glyburide (Gb) and its active metabolites, 4–trans–
hydroxygIibenclamide (Ml) and 3–cis–hydroxyglibenclamide (M2), were compared in eight …