Regulation and targeting of SREBP-1 in hepatocellular carcinoma
F Su, A Koeberle - Cancer and Metastasis Reviews, 2024 - Springer
Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …
Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD
Functional loss of TDP-43, an RNA binding protein genetically and pathologically linked to
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leads to the …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leads to the …
PRMT1 loss sensitizes cells to PRMT5 inhibition
PRMT5 is an arginine methyltransferase that accounts for the vast majority of the symmetric
methylation in cells. PRMT5 exerts its function when complexed with MEP50/WDR77. This …
methylation in cells. PRMT5 exerts its function when complexed with MEP50/WDR77. This …
Transcription-associated events affecting genomic integrity
R Sebastian, P Oberdoerffer - … Transactions of the …, 2017 - royalsocietypublishing.org
Accurate maintenance of genomic as well as epigenomic integrity is critical for proper cell
and organ function. Continuous exposure to DNA damage is, thus, often associated with …
and organ function. Continuous exposure to DNA damage is, thus, often associated with …
CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair
A critical determinant of DNA repair pathway choice is REV7, an adaptor that binds to
various DNA repair proteins through its C-terminal seatbelt domain. The REV7 seatbelt …
various DNA repair proteins through its C-terminal seatbelt domain. The REV7 seatbelt …
Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation
G Ding, X Xu, D Li, Y Chen, W Wang, D Ping… - Cell Death & …, 2020 - nature.com
Pancreatic adenocarcinoma (PDAC) is an extremely malignant tumor that is associated with
low survival rates. Fisetin is a natural flavonoid that shows diverse antitumor effects …
low survival rates. Fisetin is a natural flavonoid that shows diverse antitumor effects …
Opposing roles of FANCJ and HLTF protect forks and restrain replication during stress
The DNA helicase FANCJ is mutated in hereditary breast and ovarian cancer and Fanconi
anemia (FA). Nevertheless, how loss of FANCJ translates to disease pathogenesis remains …
anemia (FA). Nevertheless, how loss of FANCJ translates to disease pathogenesis remains …
Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t (4; 14) translocation
J Wang, X Zhu, L Dang, H Jiang, Y Xie… - The Journal of …, 2022 - Am Soc Clin Investig
The chromosomal t (4; 14)(p16; q32) translocation drives high expression of histone
methyltransferase nuclear SET domain–containing 2 (NSD2) and plays vital roles in multiple …
methyltransferase nuclear SET domain–containing 2 (NSD2) and plays vital roles in multiple …
HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair
Abstract The 53BP1-dependent end-joining pathway plays a critical role in double-strand
break (DSB) repair. However, the regulators of 53BP1 in chromatin remain incompletely …
break (DSB) repair. However, the regulators of 53BP1 in chromatin remain incompletely …
Glycosaminoglycan functionalization of electrospun scaffolds enhances Schwann cell activity
Nerve fibers of the peripheral nervous system (PNS) have a remarkable ability to regenerate
up to an almost complete recovery of normal function following a crush or a Sunderland …
up to an almost complete recovery of normal function following a crush or a Sunderland …