Guzik and Touyz Oxidation and Inflammation in Vascular Aging 661 and endothelium. 22
Perivascular fibrosis is greatly dependent on immune cells because it is prevented in …

Arterial stiffness progressively increases with aging and is an independent predictor of
cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the …

Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …

538 Hypertension September 2018 or near normal LV ejection fractions, consistent with the
clinical picture of HFpEF. In the I-PRESERVE study (Irbesartan in Heart Failure With …

As the prevalence of obesity continues to grow worldwide, the health and financial burden of
obesity-related comorbidities grows too. Cardiovascular disease (CVD) is clearly associated …

Background Arterial stiffness is emerging as an independent risk factor for the development
of chronic kidney disease. The sodium glucose co-transporter 2 (SGLT2) inhibitors, which …

Rationale: Enhanced activation of the mineralocorticoid receptors (MRs) in cardiovascular
tissues increases oxidative stress, maladaptive immune responses, and inflammation with …

Obesity is a major risk factor for cardiovascular disease in males and females. Whether
obesity triggers cardiovascular disease via similar mechanisms in both the sexes is …