Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Proteins regulate many cellular functions and analyzing the presence and abundance of
proteins in biological samples are central focuses in proteomics. The discovery and …

The integrity of quantitative proteomic experiments depends on the reliability and the
robustness of the protein extraction, solubilization, and digestion methods utilized …

Interleukin-34 (IL-34) is highly expressed in brain. IL-34 signaling via its cognate receptor,
colony-stimulating factor-1 receptor (CSF-1R), is required for the development of microglia …

Successful specification of the two mouse blastocyst inner cell mass (ICM) lineages (the
primitive endoderm (PrE) and epiblast) is a prerequisite for continued development and …

Despite the advances in molecularly targeted therapies, delivery across the blood-brain
barrier (BBB) and the targeting of brain tumors remains a challenge. Like brain, bone is a …

Instrument miniaturization is one of the critical issues to improve sensitivity, speed,
throughput, and to reduce the cost of analysis. Microfluidics possesses the ability to handle …

In this Inaugural Article, I trace some key steps that have enabled the development of mass
spectrometry for the study of intact protein complexes from a variety of cellular environments …

The coronavirus pandemic caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) directly or indirectly affects every individual worldwide. The fight against …

Mass spectrometry (MS) has become the predominant technology to analyze proteins due to
it ability to identify and characterize proteins and their modifications with high sensitivity and …