Interaction of polyethylene glycol with cytochrome c investigated via in vitro and in silico approaches
One of the significant proteins that have attracted research groups due to virtue of being a
potent selective anticancer drug target and property of triggering apoptosis upon release in …
potent selective anticancer drug target and property of triggering apoptosis upon release in …
Macromolecular crowding: how shape and interaction affect the structure, function, conformational dynamics and relative domain movement of a multi-domain protein
The cellular environment is crowded by macromolecules of various sizes, shapes, and
charges, which modulate protein structure, function and dynamics. Herein, we contemplated …
charges, which modulate protein structure, function and dynamics. Herein, we contemplated …
Macromolecular crowding modulates α-synuclein amyloid fiber growth
The crowdedness of living cells, hundreds of milligrams per milliliter of macromolecules,
may affect protein folding, function, and misfolding. Still, such processes are most often …
may affect protein folding, function, and misfolding. Still, such processes are most often …
Biophysical elucidation of fibrillation inhibition by sugar osmolytes in α-lactalbumin: multispectroscopic and molecular docking approaches
Protein aggregation is among the most challenging new frontiers in protein chemistry as well
as in molecular medicine and has direct implications in protein misfolding. This study …
as in molecular medicine and has direct implications in protein misfolding. This study …
[HTML][HTML] Protein folding mechanism revealed by single-molecule force spectroscopy experiments
H Sun, Z Guo, H Hong, P Yu, Z Xue, H Chen - Biophysics Reports, 2021 - ncbi.nlm.nih.gov
Force spectroscopy experiments use mechanical force as a control factor to regulate the
folding and unfolding process of proteins. Atomic force microscopy has been widely used to …
folding and unfolding process of proteins. Atomic force microscopy has been widely used to …
Quantitative evaluation of macromolecular crowding environment based on translational and rotational diffusion using polarization dependent fluorescence correlation …
J Yamamoto, A Matsui, F Gan, M Oura, R Ando… - Scientific reports, 2021 - nature.com
Macromolecular crowding (MMC) in cells is a hot topic in biology; therefore, well-
characterized measurement standards for the evaluation of the nano-environment in MMC …
characterized measurement standards for the evaluation of the nano-environment in MMC …
Size-Dependent Interplay of Volume Exclusion Versus Soft Interactions: Cytochrome c in Macromolecular Crowded Environment
Even though there are a great number of possible conformational states, how a protein
generated as a linear unfolded polypeptide efficiently folds into its physiologically active …
generated as a linear unfolded polypeptide efficiently folds into its physiologically active …
Potential of Osmolytes as Diagnostic Biomarkers in Various Diseases
Osmolytes are low-molecular-weight organic compounds that protect cells from extreme
stress conditions by regulating osmotic pressure and maintaining cellular homeostasis …
stress conditions by regulating osmotic pressure and maintaining cellular homeostasis …
[HTML][HTML] Unveiling the Catalytic Roles of DsBBS1 and DsBBS2 in the Bibenzyl Biosynthesis of Dendrobium sinense
L Liu, H You, L Ye, Q Ou, Y Zhao, J Wang, J Niu - Molecules, 2024 - mdpi.com
Dendrobium sinense, an endemic medicinal herb in Hainan Island, is rich in bibenzyl
compounds. However, few studies have explored the molecular mechanisms of bibenzyl …
compounds. However, few studies have explored the molecular mechanisms of bibenzyl …
[HTML][HTML] Structural refolding and thermal stability of myoglobin in the presence of mixture of crowders: importance of various interactions for protein stabilization in …
The intracellular environment is overcrowded with a range of molecules (small and large),
all of which influence protein conformation. As a result, understanding how proteins fold and …
all of which influence protein conformation. As a result, understanding how proteins fold and …