The impaired response inhibition and salience attribution (iRISA) model proposes that
impaired response inhibition and salience attribution underlie drug seeking and taking. To …

Alcohol misuse and addiction are major international public health issues. Addiction can be
characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic …

Background Individuals with a family history of alcoholism are at much greater risk for
developing an alcohol use disorder (AUD) than youth or adults without such history. A large …

Rates of alcohol and other drug use rise sharply throughout adolescence and peak in the
early 20s. Likewise, prevalence of first-time substance use disorder (SUD) and past-year …

A core deficit in drug addiction is the inability to inhibit maladaptive drug-seeking behavior.
Consistent with this deficit, drug-addicted individuals show reliable cross-sectional …

Adolescence is a period marked by increases in risk taking, sensation seeking, and emotion
dysregulation. Neurobiological models of adolescent development propose that lagging …

Background Our previous work characterized altered cerebral activations during cognitive
control in individuals with alcohol dependence (AD). A hallmark of cognitive control is the …

Adolescence is a period in which brain structures involved in motivation and cognitive
control continue to develop and also a period in which many youth begin substance use …

Prior research has found that food addiction is associated with reward-related neural
differences, but research has yet to examine whether there are also neural differences in …

Understanding factors that contribute to the escalation of alcohol consumption is key to
understanding how an individual transitions from non/social drinking to AUD and to …