Single-cell sequencing-based methods for profiling gene transcript levels have revealed
substantial heterogeneity in expression levels among morphologically indistinguishable …

Most human tumors are composed of genetically and phenotypically heterogeneous cancer
cell populations, which poses a major challenge for the clinical management of cancer …

We perform a thorough analysis of RNA velocity methods, with a view towards
understanding the suitability of the various assumptions underlying popular …

Mammalian gene expression is inherently stochastic,, and results in discrete bursts of RNA
molecules that are synthesized from each allele,,,–. Although transcription is known to be …

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …

The spatiotemporal regulation of gene expression is key to many biological processes.
Recent imaging approaches opened exciting perspectives for understanding the intricate …

Many mammalian genes are transcribed during short bursts of variable frequencies and
sizes that substantially contribute to cell-to-cell variability. However, which molecular …

Transcription is a highly regulated and inherently stochastic process. The complexity of
signal transduction and gene regulation makes it challenging to analyze how the dynamic …

Despite the well-established role of nuclear organization in the regulation of gene
expression, little is known about the reverse: how transcription shapes the spatial …

Monitoring transcription in living cells gives access to the dynamics of this complex
fundamental process. It reveals that transcription is discontinuous, whereby active periods …