P53 in the impaired lungs

MA Uddin, N Barabutis - DNA repair, 2020 - Elsevier
Our laboratory is focused on investigating the supportive role of P53 towards the
maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome …

[HTML][HTML] Diversity of lipid function in atherogenesis: a focus on endothelial mechanobiology

S Kotlyarov - International journal of molecular sciences, 2021 - mdpi.com
Atherosclerosis is one of the most important problems in modern medicine. Its high
prevalence and social significance determine the need for a better understanding of the …

[HTML][HTML] Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p

Y Bai, X Liu, Q Chen, T Chen, N Jiang, Z Guo - Scientific Reports, 2021 - nature.com
Oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell dysfunction is a
significant event in the progression of atherosclerosis. Even Myricetin (Myr) has been …

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis

Z Sun, W Chen, Z Wang, S Wang, J Zan, L Zheng… - Clinical …, 2022 - Elsevier
Atherosclerosis, characterized as the chronic inflammation of the arterial wall, is one of the
leading causes of coronary artery disease (CAD), and macrophages are found to play …

[HTML][HTML] OxLDL induces membrane structure rearrangement leading to biomechanics alteration and migration deficiency in macrophage

L Rezende, NF Do Couto, W Fernandes-Braga… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Cholesterol sequestration from plasma membrane has been shown to induce lipid packing
disruption, causing actin cytoskeleton reorganization and polymerization, increasing cell …

[HTML][HTML] Effect of LDL Extracted from Human Plasma on Membrane Stiffness in Living Endothelial Cells and Macrophages via Scanning Ion Conductance Microscopy

D Kiseleva, V Kolmogorov, V Cherednichenko… - Cells, 2024 - mdpi.com
Mechanical properties of living cells play a crucial role in a wide range of biological
functions and pathologies, including atherosclerosis. We used low-stress Scanning Ion …

P53 in endothelial function and unfolded protein response regulation

KT Kubra, N Barabutis - Cell biology international, 2022 - Wiley Online Library
Vascular barrier dysfunction due to endothelial hyperpermeability has been associated with
the pathophysiology of sepsis and severe lung injury, which may inflict acute respiratory …

Cellular and molecular mechanisms underlying plasma membrane functionality and integrity

M Vasconcelos-Cardoso… - Journal of Cell …, 2022 - journals.biologists.com
The plasma membrane not only protects the cell from the extracellular environment, acting
as a selective barrier, but also regulates cellular events that originate at the cell surface …

OGG1 prevents atherosclerosis-induced vascular endothelial cell injury through mediating DNA damage repair

Y Zhang, G Wang, M Xu, G Jin - Clinical Hemorheology and …, 2024 - content.iospress.com
OBJECTIVE: This study was designed to investigate the role of 8-oxoguanine DNA
glycosylase 1 (OGG1) in preventing atherosclerosis-induced vascular EC injury, thereby …

[HTML][HTML] OxLDL induces the release of IL-1β from primed human endothelial and smooth muscle cells via different caspase-1-dependent mechanisms

M Almansouri, P Patel, J Chamberlain… - Vascular …, 2022 - vb.bioscientifica.com
Atherosclerosis is characterised by abnormal lipid and cell accumulation within arterial
layers that leads to disturbed blood flow. Modified cholesterol forms such as oxidised low …