[HTML][HTML] Non-invasive assessment of oocyte developmental competence

TCY Tan, KR Dunning - Reproduction, Fertility and Development, 2022 - CSIRO Publishing
Oocyte quality is a key factor influencing IVF success. The oocyte and surrounding cumulus
cells, known collectively as the cumulus oocyte complex (COC), communicate bi …

Noninvasive metabolic profiling of cumulus cells, oocytes, and embryos via fluorescence lifetime imaging microscopy: a mini-review

M Venturas, X Yang, D Sakkas… - Human …, 2023 - academic.oup.com
A major challenge in ART is to select high-quality oocytes and embryos. The metabolism of
oocytes and embryos has long been linked to their viability, suggesting the potential utility of …

Non-invasive, label-free optical analysis to detect aneuploidy within the inner cell mass of the preimplantation embryo

TCY Tan, SB Mahbub, JM Campbell… - Human …, 2022 - academic.oup.com
STUDY QUESTION Can label-free, non-invasive optical imaging by hyperspectral
autofluorescence microscopy discern between euploid and aneuploid cells within the inner …

Metabolic state of human blastocysts measured by fluorescence lifetime imaging microscopy

M Venturas, JS Shah, X Yang, TH Sanchez… - Human …, 2022 - academic.oup.com
STUDY QUESTION Can non-invasive metabolic imaging via fluorescence lifetime imaging
microscopy (FLIM) detect variations in metabolic profiles between discarded human …

Optical imaging detects metabolic signatures associated with oocyte quality

TCY Tan, HM Brown, JG Thompson… - Biology of …, 2022 - academic.oup.com
Oocyte developmental potential is intimately linked to metabolism. Existing approaches to
measure metabolism in the cumulus oocyte complex (COC) do not provide information on …

[HTML][HTML] Pre-Implantation Bovine Embryo Evaluation—From Optics to Omics and Beyond

RAC Rabel, PV Marchioretto, EA Bangert, K Wilson… - Animals, 2023 - mdpi.com
Simple Summary With conventional breeding practices, even the best dairy/beef cows will
likely produce no more than half-a-dozen calves in their lifetimes; a crime, would you not …

[HTML][HTML] DMD-based hyperspectral microscopy with flexible multiline parallel scanning

X Dong, G Tong, X Song, X Xiao, Y Yu - Microsystems & …, 2021 - nature.com
As one of the most common hyperspectral microscopy (HSM) techniques, line-scanning
HSM is currently utilized in many fields. However, its scanning efficiency is still considered to …

Clinical applications of non‐invasive multi and hyperspectral imaging of cell and tissue autofluorescence beyond oncology

JM Campbell, SB Mahbub, A Habibalahi… - Journal of …, 2023 - Wiley Online Library
Hyperspectral and multispectral imaging of cell and tissue autofluorescence employs
fluorescence imaging, without exogenous fluorophores, across multiple excitation/emission …

[HTML][HTML] Vitrification within a nanoliter volume: oocyte and embryo cryopreservation within a 3D photopolymerized device

SH Yagoub, M Lim, TCY Tan, DJX Chow… - Journal of Assisted …, 2022 - Springer
Purpose Vitrification permits long-term banking of oocytes and embryos. It is a technically
challenging procedure requiring direct handling and movement of cells between potentially …

Metabolic imaging of human embryos is predictive of ploidy status but is not associated with clinical pregnancy outcomes: a pilot trial

D Sakkas, C Gulliford, G Ardestani, O Ocali… - Human …, 2024 - academic.oup.com
STUDY QUESTION Does fluorescence lifetime imaging microscopy (FLIM)-based metabolic
imaging assessment of human blastocysts prior to frozen transfer correlate with pregnancy …