Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …

Immune cell infiltration into solid tumors, their movement within the tumor microenvironment
(TME), and interaction with other immune cells are controlled by their directed migration …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Chemokines are small secreted proteins that orchestrate migration and positioning of
immune cells within the tissues. Chemokines are essential for the function of the immune …

Abstract Interleukin-8 (CXCL8) was originally described as a chemokine whose main
function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on …

CXCL1 is one of the most important chemokines, part of a group of chemotactic cytokines
involved in the development of many inflammatory diseases. It activates CXCR2 and, at high …

Persistent infection or chronic inflammation contributes significantly to tumourigenesis and
tumour progression. CXC motif ligand 8 (CXCL8) is a chemokine that acts as an important …

The presence of neutrophils in tumors has traditionally been considered to be indicative of a
failed immune response against cancers. However, there is now evidence showing that …

Breast cancer stem-like cells (CSCs) are an important therapeutic target as they are
purported to be responsible for tumor initiation, maintenance, metastases, and disease …

In humans, Interleukin-8 (IL-8 or CXCL8) is a granulocytic chemokine with multiple roles
within the tumor microenvironment (TME), such as recruiting immunosuppressive cells to the …