Platelets have traditionally been viewed as fragmentary mediators of coagulation. However,
recent molecular and cellular evidence suggests that they have multiple roles in host …

Platelets have been shown to cover a broad range of functions. Besides their role in
hemostasis, they have immunological functions and thus participate in the interaction …

Patients with cirrhosis may display impaired or enhanced platelet activation, but the reasons
for these equivocal findings are unclear. We investigated if bacterial lipopolysaccharide …

Lipopolysaccharide (LPS) from the cell envelope of Gram-negative bacteria is a principal
cause of the symptoms of sepsis. LPS has been reported to modulate the function of …

The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We
performed in vitro and ex vivo studies in controls and in patients with community-acquired …

Introduction Sepsis leads to an activation of the immune system and hemostatis. However,
studies on platelet aggregation in severe sepsis using impedance aggregometry have not …

Objectives Platelet activation seems to be implicated in the cardiovascular events occurring
in patients with community-acquired pneumonia (CAP) but the underlying mechanism is still …

In endotoxemic models, the inflammatory parameters are altered to a favorable direction as
a response to activation of cannabinoid receptors 1 and 2. The phytocannabinoid Δ9 …

Vascular complications resulting from atherosclerosis development are a major cause of
death. Reactive oxygen species (ROS) are produced by platelets during activation, and …

Essentials• Escherichia coli (Ecoli)‐mediated sepsis is a serious illness associated with
thrombocytopenia.• Gram‐positive bacteria‐induced platelet activation has been …